SignalP

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signalP predicts the presence and location of signal peptide cleavage sites in amino acid sequences from different organisms: Gram-positive prokaryotes, Gram-negative prokaryotes, and eukaryotes. The method incorporates a prediction of cleavage sites and a signal peptide/non-signal peptide prediction based on a combination of several artificial neural networks and hidden Markov models.

[edit] Availability

Version 3.0:

  • biobase.ist.unomaha.edu
  • klab.ist.unomaha.edu
  • phylogeny.ist.unomaha.edu

[edit] Installation

In a ubuntu box, do the following to install signalP: 

1. Download and extract signalp-3.0.Linux.tar.Z
2. mv signalp-3.0 /usr/local/
3. cd /usr/local/ ; ln -s signalp-3.0 signalp
4. apt-get install gnuplot
5. apt-get install gv
6. apt-get install netpbm
7. cd signalp; vim signalp (Edit the installation directory location of signalp in the file)
8. Make sure /usr/local/signalp is included in the environmental variable PATH.
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